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Abstracts
of Evaluation Studies
of Microhydrin®
A Functional Silicate Nanocolloid
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Clinton H. Howard and Kimberly Lloyd
Revised January, 2000
Royal BodyCare
is conducting an ongoing series of laboratory and clinical studies designed
to evaluate the nutritional characteristics and benefits of Microhydrin
(250 mg per capsule) as a mineral antioxidant. The following is a brief
summary of the results of studies completed as of January 2000.
Microhydrin®
Effectively Lowered Blood Lactic Acid Levels During Strenuous Exercise
The Exercise Physiology
Department of the University of North Texas Health Science Center at
Fort Worth, Texas conducted a double blind, placebo controlled crossover
study in 6 male cyclists for blood lactic acid (lactate) clearance during
a 40K (24.8 mi) timed bicycle ride at maximum speed. Subjects received
4 capsules of Microhydrin or placebo daily taking one in the morning,
two at noon and one in the evening during the week prior to testing
and during the week of testing. Subjects refrained from all other non-prescribed
supplements during the testing period. Additionally, subjects took 2
capsules with water 30 min. before the start of exercise. Blood lactate
levels was measured before and 5 min. after each exercise session. Microhydrin
significantly decreased blood lactic acid (lactate) levels as compared
to placebo during strenuous exercise (p = 0.03). (Unpublished data
Peter Raven Ph.D. 1999 & Wendy Wasmund, B.S. University of North
Texas Health Science Center at Fort Worth, 1999.)
Lactic acid accumulates
during strenuous or prolonged exercise. It is a common problem for athletes,
people who work out, play sports or do physical exercise for an extended
time.
The decreased lactic
acid (lactate) levels immediately after strenuous exercise is another
indicator of the ability of Microhydrin to help in providing a direct
energy source (ATP production) to cellular function. An ergogenic energy
function is when a substance enhances biochemical energy without introducing
additional carbohydrates or calories to the diet.
Microhydrin
in Intra and Extra Cellular Hydration
A double blind
placebo controlled pilot study was conducted using the RJL Bioelectrical
Impedance Analyzer that measures hydration of the body based on nutritional
status developed by R. J. Liedtke. Seven subjects received 4 capsules
of Microhydrin per day for two weeks and were crossed over receiving
4 capsules per day of a placebo (rice bran flour). Averaged values showed
increased intracellular and extracellular hydration due to the consumption
of Microhydrin as compared to the placebo group.
The increase observed in Extracellular Water values were statistically
significant (p < 0.05) when consuming Microhydrin as compared
to taking the placebo. (Unpublished data Gary Osborn R.Ph. &
Heriberto Salinas, MD Texas Institute of Functional Medicines, 1999)
Body Cell Mass
(BCM) and Intracellular Water (ICW) are assessments of intracellular
volume and water inside the cell, respectively. Extracellular Body
Water, water that bathes the cells, also showed increased volume.
Intracellular water makes up approximately 60% of the total body
water of healthy adults. Intracellular water, as an indicator of
cell integrity, is found to be higher in babies but decreases as
adults age or lose body cell mass. Healthy tissue cells hold water
within the cells and have higher anabolic (building up) function
rather than catabolic (breaking down) function.
Microhydrin Protection
Against Oxidative Stress
A double blind placebo
controlled crossover pilot study was conducted on 7 subjects who received
4 capsules/day of Microhydrin for two weeks, and received 4 capsules/day
of a placebo for two weeks. Urine alkenal/creatinine ratios were measured.
During Microhydrin supplementation, a 43% increase in free radical protection
was observed as compared to the placebo group. Microhydrin was observed
in this study to protect against serum alkenals. Alkenals are the oxidative
products of serum lipid peroxides occurring from free radical attacks
on cellular lipid membranes and lipoproteins. They are indicators of
free radical damage in the body associated with a higher risk of age
related diseases. (Unpublished data Gary Osborn R.Ph. & Heriberto
Salinas, MD Texas Institute of Functional Medicines, 1999)
Evaluation of
Microhydrin in the Production of NADH in Vitro
ATP production,
the principal source of energy in the mitochondria, depends on the production
of NADH. Reduced hydrogen, generated by the Kreb’s Cycle, is carried
by NADH into the mitochondria for the electron transport chain reactions
that will ultimately create a molecule of water and ATP.
Hydrogen is one
of the most important elements donating an electron, an electron pair
or its proton to reduction/oxidation reactions of numerous enzymes and
intermediates within the cell’s metabolic pathways. In vitro assays
measured the direct conversion of NAD+ to
NADH
by the addition of Microhydrin. The sequential addition of increasing
concentrations of Microhydrin to NAD+ showed a linear increase in NADH
production as measured by its absorption at 350 nm. (Unpublished
data Joe McCord, Ph.D University of Colorado Health Sciences Center,
1998).
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These
statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent disease.
Copyright©
2000 Royal BodyCare, Inc. All Rights Reserved.
This publication may not be copied, photocopied, reproduced, translated,
or convereted to any electronic or machine-readible form in whole or
in part
without prior written approval of Royal BodyCare, Inc.
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Todd N. Thompson 800-228-9810 ext. 325
